Histopathology Solutions
At Gnome Sciences, we offer a wide array of standard and specialized pathology laboratory solutions to meet the diverse needs of researchers and clinicians. Our precision-driven services are carried out in CLIA-certified molecular biology and pathology laboratories, ensuring superior quality with efficient delivery. Our laboratories are managed by board-certified pathologists and a highly skilled laboratory team, dedicated to delivering exceptional histopathology services.
Explore Your Histopathology Requirements with Our Experts:
Histopathology Expertise
Tissue Preparation and Sectioning
Rely on our experienced scientists for guidance on optimal practices for tissue collection, storage, and fixation, ensuring the integrity of both human and animal samples. From fresh or frozen tissue, we conduct quality control, fixation, processing, embedding, and sectioning. Our meticulous selection of the right microtome for each application guarantees high-quality FFPE samples for your studies, and our detailed microscopic analysis confirms the optimal tissue type and orientation on the slides. Our team can also develop tissue microarrays (TMAs) tailored to your project needs.
Staining Proficiency
At Gnome Sciences, we deliver a comprehensive array of standard chemical stains such as Hematoxylin & Eosin (H&E), alongside other specialized stains for various cellular compartments, tissues, molecules, and structures. Our proficient scientists collaborate with you to establish the most suitable reagents and methods for your project. We excel in protein and nucleic acid detection in tissues and biospecimens, utilizing Immunohistochemistry (IHC) and In Situ Hybridization (ISH/RNAScope®) techniques for precise quantification and localization.
Ventana BenchMark Ultra
Gnome Sciences leverages the Ventana BenchMark Ultra system to deliver automated, high-quality IHC and in situ hybridization (ISH) staining across a wide range of tissue-based research applications. The system provides standardized staining conditions and independent slide processing, allowing our experienced histopathology team to efficiently manage studies ranging from small proof-of-concept projects to large-scale research and clinical studies. The Ventana BenchMark Ultra also supports a broad portfolio of clinically validated IHC and ISH assays, providing our scientists with the ability to incorporate clinically relevant biomarkers and diagnostic testing methods into translational research studies. By combining advanced automated staining technology with our expertise in histopathology, molecular pathology, and biomarker analysis, Gnome Sciences can deliver consistent, reproducible tissue staining while supporting increasingly complex multi-marker studies.
Ventana Discovery Ultra
Gnome Sciences also utilizes the Ventana Discovery Ultra system to support advanced automated IHC and in situ hybridization applications requiring flexible assay development and optimized tissue staining protocols. The platform provides extensive control over staining conditions, enabling our histopathology team to tailor protocols for challenging tissue types, specialized biomarkers, and comprehensive detection workflows. This flexibility is particularly valuable for developing and optimizing novel assays, multiplex staining approaches, and studies involving low-abundance or difficult-to-detect targets. The Ventana Discovery Ultra expands Gnome Sciences’ capacity to investigate complex tissue biomarkers and establish customized staining strategies for your specialized research studies.
Digital Pathology Solutions
We harness state-of-the-art information systems to guarantee quality, regulatory compliance, comprehensive tracking of your samples, detailed analysis of results, and secure data reporting. Our processes include Aperio whole slide scanners and image analysis software that automate tasks for statistically significant outcomes, supervised by senior lab directors. Benefit from high-resolution, publication-ready digital images and our expert interpretation, accessible securely via our custom lab services portal.
Advanced Services
Gnome Sciences offers Laser Microdissection and Pressure Catapulting (LMPC) for refined single-cell analysis, employing the Zeiss PALM Microbeam IV for superior preservation of cellular and biological integrity across a wide range of workflows. Our extended molecular pathology solutions include nucleic acid isolation, quantification of specific protein and nucleic acid molecules (biomarkers), and genome variant analysis in tissue samples, including tumor biopsy regions. For additional requirements, our team is adept at developing, validating, and implementing protocols for diverse research and clinical study methods, scaling seamlessly from proof-of-concept studies.
Molecular Investigation Tools
FAQs:
At Gnome Sciences, we specialize in handling projects of all scales, from study-scale to lab-scale to department scale, involving tens to thousands of samples/specimens. We pride ourselves on delivering swift, high-quality results for projects of every size, irrespective of budget constraints. We understand the significance of every research project and are committed to providing each of our clients, regardless of their size, with the highest level of service and attention.
Absolutely. Gnome Sciences regularly collaborates with a diverse range of entities, encompassing pharmaceutical and biotechnology companies, academic and governmental research institutions, Clinical Research Organizations (CROs), research foundations, startups, and other organizations within the healthcare and life sciences sectors. We provide our services to a wide range of clients, from individual researchers or clinicians to larger labs, multi-site projects, departments, and entire organizations.
We have extensive experience handling a diverse spectrum of biospecimen types. Our work encompasses human and animal tissue (whether fresh or frozen), Formalin-Fixed Paraffin-Embedded (FFPE) specimens, tissue blocks, and tissue microarrays. We also deal with cell cultures, single cells, cell fractions, cell or tissue lysates, and hepatocytes. Furthermore, we handle whole blood, lymphocytes, buffy coats, plasma, serum, liquid biopsies, urine, biopsy samples, buccal scrapes/swabs, saliva, exosomes/extracellular vesicles, and purified samples among others.
Absolutely, Gnome Sciences is well-versed in handling COVID-19 related studies. We are recognized as a registered COVID-19 RT-PCR testing facility serving numerous healthcare organizations across Ohio. Our team has significantly contributed to the scientific community by publishing influential papers about SARS-CoV-2 pathology. Moreover, we’ve recently enhanced our services to include clinical-grade DNA sequencing for identifying viral genome variants. You can be confident that we will merge our COVID-19 expertise with our broad spectrum of pathology services to meet your specific research needs.
Absolutely, Gnome Sciences is fully equipped to collaborate with you in various capacities during your grant application process. This can range from acting as a vendor providing a detailed quote, to becoming a fully-fledged partner. Our past engagements include partnerships with academic institutions as a sub-awardee, where we provided a Co-Principal Investigator and contributed to the grant writing process. In other instances, we’ve delivered letters of support or contributed to SBIR grant sections as a contractor. Please share your specific needs and we’ll ensure that we provide the necessary assistance now, and upon successful grant funding, we will continue to support your research endeavors.
Certainly, Gnome Sciences is well-equipped with the requisite experience and certifications to provide contract laboratory services spanning the entire breadth of your project – from research and development stages to pre-clinical studies, clinical trials, and even the implementation of Laboratory Developed Tests. Reach out to us with your specific needs, and we will provide a tailored quote outlining the exact services you require.
