Advancing Antibody Efficacy: Optimization for Your Studies

At Gnome Sciences, we provide indispensable antibody optimization services to guarantee the most effective antibody and study protocols are incorporated in your Immunohistochemistry (IHC) Pathology Studies. Executed in our CLIA-certified molecular biology and pathology laboratories, our precision laboratory research services uphold the highest standards of quality, while ensuring a swift turnaround. Our laboratories are managed by board-certified pathologists and seasoned laboratory personnel, contributing to the high standards we strive to maintain.

Start a Conversation with Our Scientists about Your Novel Antibody Optimization Needs

Service Overview

Antibody Optimization Refinements

Our seasoned scientists at Gnome Sciences stand ready to assist you in selecting and fine-tuning the antibodies critical to your IHC studies. This encompasses the selection of appropriate proteins and epitopes to ensure the desired specificity in your IHC tissue investigations, including the type of antibody (mono- or polyclonal), species, and label. Moreover, we can adjust the specimen preparation procedure, focusing on fixation and antigen retrieval, to optimize the detection of your simultaneous protein biomarkers in the context of other stains and treatments. Each antibody necessitates optimization for its concentration and incubation conditions to augment signal and quantitative detection range while reducing background levels and cross-reactivity. We will select and validate the necessary controls. Finally, we can either carry out the research, develop and validate the complete detection protocol across multiple slides, and execute your studies, or we can transfer the newly developed protocols back to your scientists for study execution.

Additional Method Development, Validation, & Execution Services incorporate:

Protocol design and development
Assay Development
Method validation
Guidance on method selection
Molecular characterizations and customized biomarker assays
Reference Lab service provision
Contract Research Services
Data management and reporting (using our validated LIMS system, SOPs, etc.)
Regular reporting and progress meetings managed by dedicated project managers
Rapid Start-up, Rapid Scale-up, Rapid Delivery
CLIA-certified lab: committed to maintaining processes, standards, controls, and the quality of research and data
Our team brings to the table hundreds of years of combined industry experience

Customized Services for Early-Stage Companies

At Gnome Sciences, we recognize the specific needs and challenges of startups. We offer competitive pricing to emerging life sciences and biotech/pharma enterprises without compromising our clinical-grade quality.

Common studies for startups encompass:

Tailored Tissue Preparation

Histopathology, including slide staining and imaging
Biomarker characterization and cellular localization
Pharmacogenomic Testing
SNP analysis and gene expression analysis in biospecimens and cell lines
Guidance for Clinical Laboratory Developed Test (LDT), such as COVID-19 PCR Testing
Nucleic Acid Isolations and Sample/Library preparation for Whole Exome/Whole Genome Sequencing
Support services for drug discovery and development: pharmacogenomics, mutational analysis in protein and pathway targets, impact of drugs on genome expression, etc.

Support for Virtual BioPharma Companies

We understand that early-stage life sciences companies are progressively adopting virtual models to enhance agility and minimize operational costs and investments. Nevertheless, these companies can’t afford to sacrifice the quality or speed of their R&D to reap these benefits. Gnome Sciences can undertake your lab work for individual steps/stages or collaborate with you throughout the entire product development process.

Grants & Publications

We’re more than willing to provide quotations for any of our studies or standard or bespoke laboratory services that you can incorporate into your grant applications (either as a supplier or as a research subcontractor). Our offering includes clinical-grade services to design, develop, and validate pathology methods, genomic assays, as well as a variety of molecular biology and advanced tissue biology services. We can assist you in obtaining the publication-quality data essential for that pivotal grant or manuscript you’re working on – the type of data that leaves no room for reviewer interpretation. We’re also ready to contract with you to deliver that compelling piece of preliminary data crucial to securing your grant.